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Publications
Read up on the latest technical publications out of Team Stemloop, as well as from our technical partner affiliates.
August 3, 2023
Detection of chemicals and molecules using cell-free biosensor lateral flow assays. This application claims the benefit of and priority to U.S. Provisional Patent Application No. 63/304,257, filed on Jan. 28, 2023, the contents of which are incorporated by reference herein its entirety.
February 27, 2022
Cell-free biosensors are powerful platforms for monitoring human and environmental health. Here, we expand their capabilities by interfacing them with toehold-mediated strand displacement circuits, a dynamic DNA nanotechnology that enables molecular computation through programmable interactions between nucleic acid strands. We develop design rules for interfacing a small molecule sensing platform called ROSALIND with toehold-mediated strand displacement to construct hybrid RNA–DNA circuits that allow fine-tuning of reaction kinetics.
July 6, 2020
Lack of access to safe drinking water is a global problem, and methods to reliably and easily detect contaminants could be transformative. We report the development of a cell-free in vitro transcription system that uses RNA Output Sensors Activated by Ligand Induction (ROSALIND) to detect contaminants in water. A combination of highly processive RNA polymerases, allosteric protein transcription factors and synthetic DNA transcription templates regulates the synthesis of a fluorescence-activating RNA aptamer.
April 3, 2020
Tracking progress towards Target 6.1 of the United Nations Sustainable Development Goals, “achieving universal and equitable access to safe and affordable drinking water for all”, necessitates the development of simple, inexpensive tools to monitor water quality.
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